OncuraLung - NSCLCTaken continuously — no infusion cycle8 effects documented
A daily targeted pill for EGFR-mutant lung cancer, usually well tolerated. The common effects are diarrhea and an acne-like rash (both early), plus dry skin and nail changes. Your team also monitors the heart (ECG/echo) and watches for uncommon lung inflammation.
Get help straight away — this is true on any regimen, on any day.
A temperature of 100.4°F (38°C) or higher during treatment can mean a serious infection while your blood counts are low. Call your team or go to the ER — do not wait it out.
Also urgent: trouble breathing or chest pain · swelling of the face, lips or throat · new confusion or fainting · shaking chills · not being able to keep fluids down.
This is standing guidance shown to everyone. Nothing on this page is based on anything about you, and nobody is monitoring you.
This regimen is taken continuously, so effects are described in the terms their sources use rather than by cycle day.
usually within the first 1-2 weeks; ongoing
Loose or frequent stools, usually starting in the first week or two. Anti-diarrheal medicine, hydration, and diet adjustments help; report if it's severe or persistent.
Call your team: More than 6 stools above normal in a day, or any with dizziness.
first 1-2 weeks; peaks weeks 2-4
An acne-like rash on the face and upper body, typically appearing in the first 1-2 weeks — often a sign the drug is active. Gentle skin care, sun protection, and sometimes an antibiotic cream/tablet help; tell your team early.
Call your team: Widespread blistering/peeling, or a rash with skin-infection signs (pus, spreading redness).
from ~weeks 2-4; builds over months
Dry, sometimes itchy or cracking skin that tends to build over the first weeks-months. Frequent moisturizing helps.
delayed (after ~4-8 weeks); builds over months
Tender, red, sometimes infected skin around the nails that tends to appear later (after about a month) and builds over time. Antiseptic soaks and careful nail care help; tell your team if painful.
often within the first few weeks; recurrent
Soreness or small ulcers in the mouth, often in the first few weeks. Gentle oral care and a bland diet help.
Call your team: Can't eat or drink because of mouth pain.
Reduced appetite that can persist. Small, frequent, high-calorie meals and dietitian support help; report ongoing weight loss.
can develop over months of daily dosing
Osimertinib can affect the heart's electrical timing (QTc) and, less often, weaken the heart's pumping. These are usually found on monitoring rather than felt. Your team does ECGs and may check an echocardiogram; report fainting, palpitations, or breathlessness.
Call your team urgently: Fainting, a fast/irregular heartbeat, or new breathlessness.
any time during daily dosing
Uncommon but serious inflammation of the lungs, causing new or worsening cough, breathlessness, or fever. Report breathing changes promptly — the drug is stopped and the problem investigated.
Call your team urgently: New or worsening breathlessness, cough, or fever — contact your team urgently.